India grasped the initiative with four wickets in the final session after half-centuries from Aiden Markram and Hashim Amla put South Africa in a promising position on day one of the second Test.
Markram continued his impressive start to his Proteas career, striking 15 boundaries in a well-crafted 94 and Amla made 82, having been dropped by wicketkeeper Parthiv Patel on 30, but India hit back after tea at Centurion.
Spinner Ravichandran Ashwin took 3-90 and Hardik Pandya produced a moment of brilliance to run out Amla as South Africa, handing a debut to paceman Lungi Ngidi, slipped from 246-3 to 269-6 at stumps.
Ishant Sharma, recalled along with Parthiv and KL Rahul in place of Bhuvneshwar Kumar, Wriddhiman Saha and Shikhar Dhawan respectively, removed AB de Villiers in a final session which ended with India in the ascendancy after toiling for much of a hot Saturday.
Amla has made at least a fifty in 10 of the 12 Tests he has played at Centurion. He averages over 80 at the venue. #SAvInd— ESPNcricinfo stats (@ESPNcric_stats) January 13, 2018
Markram and Dean Elgar saw off the new ball on a flat pitch after Faf du Plessis won the toss, the former playing a couple of exquisite off drives when the expensive Mohammed Shami over-pitched after runs had been hard to come by.
The India quicks, Shami aside, had been well disciplined, but Jasprit Bumrah was taken for 13 in an over before Virat Kohli wasted a review for caught behind when he thought Elgar had edged Ashwin through to Parthiv.
A confident Markram reached his fifty off 81 balls and South Africa moved to 78 without loss at lunch, but Murali Vijay ended an opening stand of 85, juggling to take a catch at silly point as Ashwin tempted Elgar into a loose drive.
Markram continued to punish stray deliveries that came along and looked set for a third Test hundred in just seven visits to the crease, but fell six runs short when he feathered Ashwin through to Parthiv and failed to get the decision overturned.
A diving Parthiv was unable to hold on down the leg side after Amla edged a delivery from Ishant, who was rewarded for his endeavour by removing De Villiers, the former skipper chopping on for 20 after tea.
Amla brought up his half-century by punching Ashwin to the cover boundary and appeared destined for a 29th Test hundred, only for Pandya to swoop and unleash a bullet of a throw to run him out with a direct hit.
The Proteas lost three wickets in just 14 balls to give India the upper hand, Quinton de Kock edging the impressive Ashwin to Kohli at first slip from his first delivery before Vernon Philander was run out for a duck.
Du Plessis and Keshav Maharaj prevented further damage from being done, but they will return to the crease on Sunday morning with work to do.
|Butragueno backs under-fire Lopetegui|
|Liverpool´s defensive improvement has hurt attack – Klopp|
|Butler booed by Timberwolves fans during introductions|
|Pochettino: Dier´s Ramos tackle highlighted Spurs´ attitude|
|Man City working on new deal for Sane – Guardiola|
|Golden Knights sign RW Tuch to seven-year extension|
|Bryant explains how Lakers could beat Warriors|
|Finals hopefuls Isner, Fognini into Stockholm semis|
|Browns trade running back Hyde to Jaguars|
|Mourinho: I´d love to have Hazard at Manchester United|
|Hamilton´s title chances enhanced by Vettel´s grid penalty|
|Deja vu for Enisei as La Rochelle inflict another thrashing|
|Five-star Jovic makes Bundesliga history|
|Liverpool´s scoring slump no concern for cautious Klopp|
|He´s the Special One - Sarri insists he is not on Mourinho´s level yet|
|Second-half blitz guides Leicester to European success|
|Sheffield Wednesday 1 Middlesbrough 2: Besic, Assombalonga see off Owls|
|Goerges rallies to reach Luxembourg Open final, Jabeur makes history|
|Howe: Transfer speculation will not disrupt Ake|
|´Do we really want opera every night?´ - Klopp not changing Nations League view|
|Vile and abhorrent – Chelsea´s Carney responds to online abuse|
|Giants WR Beckham Jr. explains why he might cramp up: ´I really don´t like water´|
|Man City pay training-pitch tribute to Joe Hart|
|Neymar to be rested as Tuchel rubbishes Ballon d´Or concerns|
|Sarri ´not interested´ in Christensen father´s quit threat|
|Cardinals fire offensive coordinator McCoy after 1-6 start|
|Neymar return unlikely, but anything can happen – Valverde|
|Bairstow a doubt for fourth ODI|
|Manchester United fined for late arrival and delayed kick-off against Valencia|
|Australia-Pakistan chat not ´especially polite´ - Sarfraz|
|Pogba relishing ´pressure game´ against in-form Hazard|
|Don´t bet on Cardiff survival, warns Warnock|
|Buffon enjoying Tuchel´s methods at PSG|
|RIP to Wimbledon epics! Isner feels like The Undertaker following final-set tie-break rule|
|Sevilla performance sealed Bernat´s Bayern exit - Hoeness|
|Keita set to miss out as Liverpool monitor injured stars|
|He didn´t want to be here – Guardiola doubts Sancho will return to Manchester City|
|Sarri: Manchester United are the best in the Premier League|
|Mourinho salutes ´brave´ Shaw for ´best possible´ response to criticism|
|No Ballon d´Or distractions for Griezmann, insists Simeone|
|Wigan stand by Hardaker as full-back prepares to undergo rehabilitation|
|Barcelona deny Neymar talk|
|Hazard can win the Ballon d´Or as a Chelsea player, insists Sarri|
|De Bruyne in contention to start in Manchester City´s clash with Burnley|
|Neymar needs to mature to reach Messi levels - Xavi|
|We have a hell of a lot to do - Paine slams Australia batting|
|Kerber and Osaka to meet at WTA Finals|
|Lorenzo out of Japanese MotoGP|
|Real Madrid handed Africa trip in Copa del Rey|
|Allegri: Ronaldo has sharpened Juventus focus|
|No Wade in Wasps squad amid NFL reports|
|Rooney: Five of us controlled Man United dressing room|
|Bayern bosses launch scathing attack on ´disrespectful´ media|
|Saints lock in Lawes to new deal|
|Adelaide United 1 Sydney 1: Debutant Le Fondre rescues a point|
|Madrid can´t look back, only forward - Lopetegui confident of revival|
|Wimbledon to introduce final-set tie-breaks|
|Abbas inspires Pakistan to series victory|
|Madrid boss Lopetegui hopeful on Bale availability|
|Mood is positive at Bayern, insists under-pressure Kovac|
|LeBron offers food for thought after losing Lakers debut|
|Bolt future not an immediate concern for Mariners|
|Hazard: I could finish my career at Chelsea|
|Buffon hoping to avoid Champions League final against Juventus|
|Wilshere not ready for West Ham return|
|Chelsea v Manchester United: Hazard better under Sarri than he ever was with Mourinho|
|The big Friday Premier League quiz|
|Khawaja suffers meniscal tear, doubt for India series|
|Babbel: Klopp must win trophies now at Liverpool|
|LeBron makes spectacular start on Lakers debut, but LA fall to Trail Blazers|