Cristiano Ronaldo will aim to extend his strong record of scoring against former clubs as Juventus take on Manchester United at Old Trafford in the Champions League on matchday three.
The Italian champions will hope their Portuguese star shows his old employers that he has not lost his eye for goal, while in-form Manchester City striker Sergio Aguero could have the chance to claim two goal-scoring records should he feature against Shakhtar Donetsk.
There is huge pressure on Real Madrid to claim all three points against Viktoria Plzen following another disappointing LaLiga defeat at the weekend, and Julen Lopetegui's position as head coach may depend on it.
Here, with the help of Opta data, we take a look at some of the key numbers ahead of Tuesday's Champions League fixtures.
Real Madrid v Viktoria Plzen
43 - Real Madrid have scored in each of their last 43 Champions League home matches, their most recent blank coming in a 2-0 defeat to Barcelona in April 2011.
26 - Los Blancos have an unbeaten home record in Champions League matches that stretches back 26 games to October 2009, when they were beaten 3-2 by AC Milan.
Manchester United v Juventus
2 - United's task looks all the more difficult when you consider the fact that Juventus have lost just two of their last 23 Champions League group stage games (W14, D7), with those defeats coming against Spanish opposition.
5 - Ronaldo has scored five goals in the six Champions League games he has played against his former clubs, including one in each of his appearances for Real Madrid against United.
Shakhtar Donetsk v Manchester City
50 - Should Aguero feature for Pep Guardiola's side in Donetsk, he will become the first City player to make 50 Champions League appearances for the club.
22 - Aguero's Champions League goal tally for City stands at 22, and if he scores again he will pull level with former Chelsea striker Didier Drogba as the player with the joint-most goals in the competition for an English club.
AEK Athens v Bayern Munich
5 – AEK Athens have lost five of their seven European meetings with German opponents, with the solitary win coming against Bayer Leverkusen in the 2000-01 UEFA Cup.
6 – Bayern Munich have kept a clean sheet in each of their last six matches against Greek opponents, scoring 16 goals in the process.
Young Boys v Valencia
1 – Valencia have lost just one of their 11 previous meetings with Swiss opposition, though it was their most recent away match against them – Basel in the 2013-14 Europa League.
0 – Young Boys are yet to score in the Champions League this season – they have conceded more goals (6) than they have had shots on target (5).
Ajax v Benfica
12 – Ajax's Hakim Ziyech has attempted the joint-most shots in the Champions League this season (12, level with Lionel Messi), however he has failed to find the net.
4 – Benfica won their first ever European meeting with Ajax in 1969, but are winless in their subsequent four against them (D1 L3).
Roma v CSKA Moscow
6 - Roma have won all of their last six home games in the Champions League, conceding just two goals in the process.
11 - Edin Dzeko has scored 11 Champions League goals since the start of last season - only Cristiano Ronaldo (15) has netted more in the competition during that time.
Hoffenheim v Lyon
75 – Nabil Fekir has been involved in 75 per cent of Lyon's Champions League goals this season (1 goal, 2 assists).
1 – Hoffenheim have won just one of their 10 matches in all European competition (D3 L6). Their solitary success came against Istanbul Basaksehir in last season's Europa League.
|BREAKING NEWS: Manchester United appoint Solskjaer until end of season|
|Kane a doubt for north London derby|
|Mourinho sacking changes things – Tuchel|
|Nets top Lakers in Brooklyn, extend winning streak to six games|
|LeBron on Lakers potentially acquiring Davis: That would be amazing|
|Rain helps Sri Lanka claim draw against New Zealand|
|Mourinho had to ´take the consequences´, says Klopp|
|Ausilio: Icardi has offer on table, won´t be sold to Juve|
|Chargers lead NFL Pro Bowl selections, Brees named NFC starting QB|
|Pro Bowl 2019: Chargers lead NFL with 7 selections, Drew Brees named NFC starting QB|
|Savea re-signs with All Blacks, Hurricanes|
|Flanagan facing de-registration as Sharks, Tigers cop huge fines|
|Napoli rejected £95m offer for Koulibaly amid United links – De Laurentiis|
|Kovac feels for axed United boss Mourinho|
|Rabiot, we do not need you – PSG fans respond to wantaway midfielder|
|Guardiola hails assured debut from Man City youngster Garcia|
|He´s very happy at Tottenham – Arsenal boss Emery wants Pochettino to reject Manchester United|
|Rams sign RB C.J. Anderson|
|Good luck with the Red Devils - Norway PM´s message for Solskjaer|
|Pogba was ´dancing on the grave´ of Mourinho - Neville|
|Solskjaer set to replace Mourinho after Man United gaffe|
|City signing Steffen up to Guardiola´s goalkeeper demands, says Berhalter|
|Mourinho is so strong - Guardiola backing for fallen rival|
|Mourinho? Ausilio dismisses Inter return after United sacking|
|Whyte needs to raise his game to beat Chisora again - Haye|
|Brussino leads late Tenerife rally as Venezia down Holon|
|Orleans 1 Paris Saint-Germain 2: Super sub Diaby sends holders through|
|Leicester City 1 Manchester City 1 (1-3 on penalties): Muric stands tall in poor shoot-out|
|Middlesbrough 0 Burton Albion 1: League One side reach semi-finals|
|Bologna 0 AC Milan 0: Bakayoko sent off as Inzaghi claims point against former side|
|Fortuna Dusseldorf 2 Borussia Dortmund 1: Bundesliga leaders suffer shock first loss|
|Rivera yet to make a call on sitting Panthers QB Newton|
|Pulisic would thrive in Premier League, but Berhalter expects Dortmund stay|
|Raptors coach Nurse fined by NBA for criticising referees|
|Solari ´loves´ struggling Real Madrid star Isco|
|Mourinho sacked: Pogba, Lukaku, Fred and his other Man United signings rated|
|Mourinho sacked: What does it mean for Manchester United players?|
|Ibrahimovic provides short-term pain, long-term gain for US - Berhalter|
|River Plate 2 Al Ain 2 (aet, 4-5 on penalties): Perez misses decisive spot kick|
|De Bruyne and Aguero back for City, surprise debut for Garcia|
|Uncapped Varun ´panicked a little´ after huge IPL deal|
|Replays scrapped for FA Cup fifth round|
|Pochettino readies big guns for Gunners|
|Ex-Wasps star Wade struggling with NFL transition|
|BCCI rejects ´baseless´ claims over Kohli-Paine ´banter´|
|Ibrahimovic re-signs with LA Galaxy for 2019|
|Mourinho sacked: Solari not worried for Real Madrid job|
|Mourinho sacked: 895 days and more than £700,000 in five-star luxury|
|ES Tunis 1 Guadalajara 1 (6-5 on penalties): Dhaouadi holds nerve to settle ill-tempered affair|
|Murphy lands permanent Tigers role|
|Mourinho sacked: Real Madrid´s Marcelo lauds ´great coach´ after United exit|
|Unadkat, Varun the top buys at IPL auction|
|Emery prepared to give youth a chance in north London derby|
|Tottenham extend Vertonghen contract until 2020|
|Panthers safety Reid receives seventh random drug test of 2018|
|Kovac relishing Klopp challenge in Champions League|
|Bancroft to return, teenager Lamichhane to fly the flag for Nepal in Big Bash|
|Liverpool still have plenty of work to do - Klopp|
|Messi ´never imagined´ his success after winning record fifth Golden Shoe|
|WATCH: Timberwolves´ Gibson tries to block shot with his trainer|
|Mourinho sacked: Klopp praises departed Manchester United boss|
|Mourinho sacked: Jose the best Manchester United manager since Ferguson - Gerrard|
|Mourinho sacked: Ferdinand calls for ´fresh ideas´ at Man United|
|Mourinho sacked: The mystique has gone as United spell ends in divorce|
|´He´s an interest not only for us but for many´ - Zola praises rumoured Chelsea target Wilson|
|Mourinho sacked: Pochettino focused on Spurs amid Manchester United rumours|
|Mendis eyes double-century for departing Samaraweera|
|Mourinho sacked: Zola expects Jose to be in another job ´soon´|
|Mourinho sacked: Five reasons it went wrong at Manchester United|
|Mourinho sacked: Jose´s Manchester United record in Opta stats|