Stoke City manager Mark Hughes has revealed his side could face Chelsea on Saturday with just one available central defender.
Ryan Shawcross (back) and Geoff Cameron (hamstring) are still injured, while Kurt Zouma is ineligible to play against his parent club.
Hughes also confirmed Kevin Wimmer is struggling for fitness after sustaining a hamstring injury during the 2-0 EFL Cup defeat to Bristol City on Tuesday.
That leaves Bruno Martins Indi as the only first-team centre-back for the visit of the defending Premier League champions to the bet365 Stadium.
"We're struggling a little bit defensively," he said.
"Of my senior centre-halves I've probably got one. We're keeping our fingers crossed Kevin will be okay. He's got damage to his hamstring and we're hoping it won't stop him playing, but clearly at the moment he's a big risk.
"Obviously if you have three or four injuries in the same position you haven't got depth. That's where we find ourselves and it's coincided with the fact we can't play Kurt. We're a little bit stretched, to say the least."
Hughes will be relieved his makeshift defence does not have to contend with Diego Costa, who arrived in Spain on Friday to complete his impending move to Atletico Madrid.
The Stoke boss lamented Costa's departure as "a real shame" and admits he will miss the striker's combative presence in the Premier League.
"I don't know the whole circumstances, but from a football fans' point of view I think he's a loss to the Premier League," said Hughes.
"I used to really enjoy watching him go about his business because he was different - he had an edge, and the reaction of other players to him was interesting.
"Whatever happened and why, maybe both sides should have got together and got a real positive out of it. As it is he's left Chelsea and the Premier League and that's a real shame."
|Inter 2 Fiorentina 1: D´Ambrosio maintains Nerazzurri revival|
|Oxford United 0 Manchester City 3: Foden stars as EFL Cup holders cruise into round four|
|Cousin takes Gabon post after Aubameyang rejection|
|Bayern Munich 1 Augsburg 1: Neuer error costs champions|
|Paris Saint-Germain must be a Champions League force to help Neymar - Baptista|
|Salgado warns of ´war´ in Spanish football|
|Cech deserves Arsenal place, says Seaman|
|Halep and Garcia among seeds to fall in Wuhan|
|F1 Raceweek: Mercedes taking no comfort in points advantage|
|Benitez charged by FA for referee comment relating to Zaha treatment|
|Cibulkova dumps out hampered Halep in Wuhan|
|Mourinho questions his players amid reports Pogba won´t captain United again|
|European Ryder Cup diary: Fleetwood´s hair delights Poulter|
|USA Ryder Cup diary: Tiger´s roaring reception, McEnroe´s bold prediction|
|Loans to be limited under new FIFA proposal|
|Prolific Nadolo signs new Montpellier contract|
|Modric? For us, Messi is the best – Valverde|
|Murray makes winning start in Shenzhen|
|Mickelson would cherish first victory on European soil|
|Hodge hoping pressure proves too much for South Africa|
|Woodward in show of support for under-fire Mourinho|
|Mickelson jokes he wants ´a shot a side´ from Tiger in Thanksgiving showdown|
|Reed: Captain America is a villain in Europe|
|Duminy to captain Proteas as Elgar replaces injured Amla|
|No Tottenham timeline for Lloris, Vorm returns|
|Woods ready for ´awesome environment´ on Ryder Cup opening hole|
|Tony Bellew determined to prove doubters wrong against Oleksandr Usyk|
|Tuchel explains why he likes Neymar at number 10|
|Manchester United smash revenue record but profits down|
|Furyk downplays Ryder Cup pairings talk, says Tuesday is about individuals|
|Rejuvenated Tiger out to improve poor Ryder Cup record|
|Saunders fined £100,000 for ´sickening´ online video|
|Hazard can reach his full potential with Sarri´s Chelsea - Zola|
|Ryder Cup heading back in Europe´s direction, says Niall Horan|
|Wow! Klopp hails Sarri´s Chelsea transformation|
|Giovinazzi to partner Raikkonen at Sauber in 2019|
|Bjorn backs ´phenomenal´ Rahm to continue trend of Spanish success|
|Durant in no rush to decide Warriors future|
|Rossi to face anti-doping hearing|
|Mignolet to return for Liverpool against Chelsea|
|Premier League ´interesting´ for Germany boss Low|
|Wilder wins Twitter vote to be Joshua´s next opponent|
|BREAKING NEWS: Isco an El Derbi doubt due to appendicitis|
|Juventus won´t rest Ronaldo ahead of Napoli clash|
|Slater cleared to play in NRL Grand Final|
|Top seed Begu sent packing in Tashkent|
|This isn´t my last hurrah in Ryder Cup, insists Poulter|
|Barba back in NRL with North Queensland Cowboys|
|Arsenal wait on Mkhitaryan and Sokratis|
|All Blacks wary of Pumas pack ahead of Buenos Aires Test|
|Ryder Cup has special place in Pep Guardiola´s heart, says Fleetwood|
|Mbappe ready to take over from Messi and Ronaldo, says Trezeguet|
|Molinari: Ryder Cup pressure far outweighs any major|
|Koepka heads PGA Tour´s Player of the Year nominations|
|Lampard: Mourinho still a great manager|
|United States and Europe reveal Ryder Cup practice groupings|
|Bulldogs´ fine for ´Mad Monday´ antics halved|
|Bennett to leave Broncos after 2019 NRL campaign|
|American League postseason picture becomes clear|
|Steelers edge Buccaneers for first win|
|Gatland wants Webb available for World Cup|
|Modric: Ronaldo, Messi out of this world but my season deserved recognition|
|Love says Cavs ´will surprise a lot of people´|
|George believes Thunder can compete for championship this season|
|Messi is the greatest ever – Eto´o|
|Messi to miss Argentina´s upcoming friendlies|
|Dolphins say Hayes tore ACL attempting to avoid roughing-the-passer penalty|
|Modric deserved FIFA Best award – Ramos|
|Thibodeau open to potential Butler trade|
|Modric wanted Ronaldo, Messi at awards ceremony|